Utility of research of plasma homocysteine risk factor for cardiovascular diseases in obese school children

Introduction: Elevated plasma homocysteine level is an independent risk factor for cardiovascular disease and a sensitive marker of inadequate vitamin B12 and folate status. Such high values were highlighted and in the child obesity, homocysteine can play a role in the higher risk for cardiovascular disease in these children. Many studies showed that plasma homocysteine is elevated in obese school children with hypertension and dyslipidemia, so with metabolic syndrome, this may indicate a high risk for cardiovascular diseases. Plasma homocysteine should be monitored in these children. Purpose: To research plasma Hcy values in obese child compared with a control group of non-obese children and the correlations with blood pressure values and blood levels of total cholesterol and triglyceride. Methods: Patients: 41 children aged 8-18 years, of which 31 obese and 10 non-obese, normal weights, healthy children, without cardiovascular diseases. All children received clinical examination, determination of plasma levels of homocysteine in the morning aft er 12 hour fasting, total cholesterol, triglyceride, and blood glucose. In all children there were assessed morphological and functional cardiac aspects by echocardiography. Results: Plasma levels of homocysteine were elevated in 41.6% of children with obesity, compared to the control values: the mean 8.9 ± 1.7 μmol/L vs 6.1 ± 2.4 μmol/L. Increased levels of Hcy in obese children were more important in obese children with hypertension (5 cases). Elevated Hcy were often associated with high total cholesterol ± triglycerides in obese children compared to control values. Blood glucose levels were normal. Echocardiographic changes in obese children: slight increase in LV wall thickness, dilated left atrium, LV diastolic dysfunction in 35% of cases, but with normal LV ejection fraction, mainly in cases the most increased values of Hcy. Conclusions: In obese children and mainly in those with systemic hypertension we noted an increase in plasma homocysteine values, oft en associated with elevated total cholesterol ± triglyceride levels. Research and systematic monitoring of values of plasma homocysteine correlated with cholesterol and triglyceride levels allow an objective estimation of cardiovascular risk in children with obesity and an indication for cardiovascular prevention effective measures.

ISSN – online: 2734 – 6382
ISSN-L 1220-658X
ISSN – print: 1220-658X
The Romanian Journal of Cardiology is indexed by:
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CODE: 379
CME Credits: 10 (Romanian College of Physicians)
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